สถาบันวิจัยวิทยาศาสตร์สาธารณสุข

NATIONAL INSTITUTE OF HEALTH OF THAILAND

Laboratory-based surveillance of phaeohyphomycosis from 1994-1998

Authors : Jotica Boon-long*, Nanthawan Mekha*, Kanchana Pruesapan*


Affililations:
       *Mycology Section National Institute of Health, Department of

Medical Sciences 88/7 Soi Bumrasnaradura Tivanond Road,

Nonthaburi 11000

           

Source:            Ministry of Public Health Journal 1998; 17(4-6): 107-114

           

Language:         Thai with English abstract

 

Abstract:

 

The pattern of fungal infections in humans has changed in the recent years. This is due to increasing incidences of fungal infections among immunocompromised individuals, whose numbers have increased markedly. Phaeohyphomycosis refers to various infections caused by brown-pigmented (dematiaceous) fungi; the involvement may be cutaneous, corneal, subcutaneous, paranasal sinus, central nervous system or systemic. Identification of the fungi is based mostly upon morphology and nutritional physiology. The Mycology Laboratory is the Medical Mycology Reference Laboratory for hospitals nationwide. A laboratory based surveillance of phaeohyplomycosis from 1994 to 1998 showed an increasing trend. The incident percentages were: 0.097% for 1994, 0.11% for 1995, 0.19% for 1996, 0.12% for 1997 and 1.04% for 1998. The genus Exophiala was the most frequent aetiological agent, with E. spinofera as the most common species causing 6 out of 10 infections. Cladophialophora bantiana  was also responsible for 6 tnfections. These common aetiological agents generally caused systemic infections, unlike overseas strains which either caused (sub) cutaneous infections or cerebral phaeohyphomycosis. It is important that medical personnel should be aware of phaeohyphomycosis.