Affililations: *Institute of Medical Plant Researh
**Division of Clinical Pathology, Department of Medical Sciences
Source: Bulletin of Department of Medical Sciences 1998; 40(1): 9-21
Language: Thai with English abstract
Quisqualis indica Linn. Seed has long been used in folk medicine as an ascaricide. Toxicity studies of the seed were carried out in mice and rat in order to gain more information on using as an safety human anthelmentic. Our results revealed that mice receiving water extract equivalent to the seed at the dose of 20.0 g/kg/day orally showed no acute toxicity and therefore LD50 was more than 20.0 g/kg/day. The subacute toxicity study in Wistar rats by administration of water extract equivalent to the seed at the doses of 0.2, 2.0, 6.0, 10.0 and 20.0 g/kg/day for 60 consecutive days showed that after receiving the extract equivalent to the seed of 6.0, 10.0 and 20.0 g/kg/day for 2 days, the animals showed abnormal clinical signs; the notable ones were clonic with tonic seizures followed by respiratory arrest and death. The percentages of rats presenting toxic symptoms and death at the doses of 6.0, 10.0 and 20.0 g/kg/day in male were 26, 53 and 80 respectively, and in female were 0, 6 and 80, respectively. All rats died after receiving the highest dose only for 3 consecutive days. The growth rate and feed consumption of the survived rats receiving the extract for 60 days were not different from control group. Hematological and biochemical alterations of some parameters were observed in some group of rats receiving the extract but these did not correlate with the increasing doses of the extract and hence should not be attributable to the toxicity of the Q. indica seed. Histopathological study of internal organs revealed no remarkable lesions accounted for the toxicity of the Q. indica seed.