สถาบันวิจัยวิทยาศาสตร์สาธารณสุข

National Institute of Health of Thailand

Association of IL1B –31C/T and IL1RA Variable Number of an 86-bp Tandem Repeat With Dengue Shock Syndrome in Thailand

Authors : Areerat Sa-Ngasang1,2, Jun Ohashi3, Izumi Naka3, Surapee Anantapreecha2, Pathom Sawanpanyalert4, and Jintana Patarapotikul1

 

Affiliations : 

Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok;
National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand;
Molecular and Genetic Epidemiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan; and
Food and Drug Administration, Ministry of Public Heath, Nonthaburi, Thailand

 

Source :

Journal of Infectious Diseases Advance Access published March 14, 2014

 

Language :

English

 

Abstract :

 
 

Background. Dengue patients present a range of symptoms: dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS). It is not clear whether this variability is due to their genetic background. Here we tested polymorphisms of interleukin 1 beta (IL1B) and interleukin 1 receptor antagonist (IL1RA) genes for association with DSS in the Thai population.

Methods. Polymorphisms of IL1B -31C/T (rs1143627) and IL1RA 86-base-pair tandem repeat were analyzed in 871 patients (DF = 384, DHF = 413, and DSS = 74).

Results. IL1B -31C and IL1RA 2/4 genotype were associated with DSS (IL1B -31C: DSS vs DHF: P = .0061, odds ratio [OR, 95% confidence interval {CI}], 3.49 [1.36–8.95]; DSS vs DF: P = .027, OR [95% CI], 2.81 [1.12– 7.06]; IL1RA 2/4: DSS vs DHF: P = .017, OR [95% CI], 1.94 [1.12–3.40]; DSS vs DF: P = .024, OR [95% CI], 1.90 [1.07–3.4]). No difference was found between DF and DHF. Logistic regression analysis revealed that IL1B -31C and IL1RA 2/4 genotypes were each independently associated with DSS.

Conclusions. Patients with IL1B -31C carrier, or IL1RA 2/4 genotype carry a risk for DSS, implying that IL1B may play a role in pathogenesis of DSS.

Keywords. association; dengue shock syndrome; IL1B; IL1RA.

 

Link :

OXFORD Academic : https://academic.oup.com/jid/article/210/1/138/2910542

NCBI : https://www.ncbi.nlm.nih.gov/pubmed/24446526