สถาบันวิจัยวิทยาศาสตร์สาธารณสุข

National Institute of Health of Thailand

Authors : Nagao Y1, Tawatsin A2, Thammapalo S3, Thavara U2.
Affiliations : 
1 Yao Tokushukai General Hospital, Yao, Osaka, Japan
2 National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
3 Bureau of Vector Borne Disease, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand

 

Source :
Epidemiol Infect. 2012 Mar;140(3):479-90. doi: 10.1017/S0950268811000653. Epub 2011 May 9.

 
Language : English
 

Abstract :

 
 

          Dengue haemorrhagic fever (DHF) is caused by dengue virus transmitted by Aedes mosquitoes; mean age of patients varies temporally and geographically. Variability in age of patients may be due to differences in transmission intensity or demographic structure. To compare these two hypotheses, the mean age of DHF patients from 90 districts in northern Thailand (1994-1996, 2002-2004) was regressed against (i) Aedes abundance or (ii) demographic variables (birthrate, average age) of the district. We also developed software to quantify direction and strength of geographical gradients of these variables. We found that, after adjusting for socioeconomics, climate, spatial autocorrelation, the mean age of patients was correlated only with Aedes abundance. The geographical gradient of mean age of patients originated from entomological, climate, and socioeconomic gradients. Vector abundance was a stronger determinant of mean age of patients than demographic variables, in northern Thailand.

 
PMID:21733256[PubMed - indexed for MEDLINE] PMCID:PMC3267098 Free PMC Article