สถาบันวิจัยวิทยาศาสตร์สาธารณสุข

National Institute of Health of Thailand

Antibacterial activity of teicoplanin against Clostridium diffcile

Authors : Siripan Wongwanich*, Mayura Kusum*, Ratanasuda Phan-Urai*


Affiliations:        *National Institute of Health, Department of Medical Sciences.

                        Ministry of Public Health, Nonthaburi, Thailand     
           
Source:             Southeast Asian Journal of Tropical Medicine and Public Health
1996; 27(3): 606-609    
           
Language:         English
 
Abstract:
 
The in vitro inhibitory action of teicoplanin, vancomycin, metronidazole and clindamycin against clinical isolates of Clostridium difficile was investigated. Minimum inhibitory concentrations (MICs) were determined using E test. Teicoplanin (MIC range 0.023 - 0.75 mmg/ml), vancomycin (MIC range 0.5 - 3 mmg/ml) and metronidazole (MIC range 0.19 - 1 mmg/ml) were all very active against the isolates examined. No resistant strains of C. difficile to those three antimicrobial agents were observed, whereas resistance to clindamycin was found in 39.5% of the tested strains. Teicoplanin was about 4-times more potent than vancomycin. It appears to be a more promising antimicrobial for treatment of C. difficile enteric disease.