Affiliations: *National Institute of Health, Department of Medical Sciences.
Ministry of Public Health, Nonthaburi, Thailand
Source: Southeast Asian Journal of Tropical Medicine and Public Health
1996; 27(3): 606-609
The in vitro inhibitory action of teicoplanin, vancomycin, metronidazole and clindamycin against clinical isolates of Clostridium difficile was investigated. Minimum inhibitory concentrations (MICs) were determined using E test. Teicoplanin (MIC range 0.023 - 0.75 mmg/ml), vancomycin (MIC range 0.5 - 3 mmg/ml) and metronidazole (MIC range 0.19 - 1 mmg/ml) were all very active against the isolates examined. No resistant strains of C. difficile to those three antimicrobial agents were observed, whereas resistance to clindamycin was found in 39.5% of the tested strains. Teicoplanin was about 4-times more potent than vancomycin. It appears to be a more promising antimicrobial for treatment of C. difficile enteric disease.