สถาบันวิจัยวิทยาศาสตร์สาธารณสุข

National Institute of Health of Thailand

Authors : Pranee Chavalittumrong*, Sadudee Rattanajarasroj* , Busarawan Sriwanthana**, Pranee Chantapet** ,Sirima Pattamadilok**, Paijit Warachit***


Affiliations :    *Medicinal Plant Research Institute

                        **National Institute of Health
                        *** อธิบดีกรมวิทยาศาสตร์การแพทย์ 
Department of Medical Sciences 88/7 Soi Bamrasnaradura, Tivanond Rd., Nonthaburi 11000, Thailand
 
Source:           Journal of Thai Traditional and Alternative Medicine 2005; 3(1): 17-26
 
Language:      English with Thai abstract
 
Abstract:          
                     
A phase 1 trial was performed in 12 healthy volunteers to primarily investigate safety of Derris scandens as well as to preliminary assess its effects on immune system. The volunteers received 400 mg/day of D. scandens hydroalcoholic extract (200 mg b.i.d.) for 2 months. No major side effects were reported from any of the subjects throughout the study. It was found that any significant changes in hematological and biochemical parameters were within normal limits. A significant rise in the frequencies of subjects with increasing amounts of IL-2, IL-4 and IL-6 after administration was shown. Our results suggested that the hydroalcoholic extract of D. scandens at the dose of 400 mg/day given to normal volunteers for 2 months was safe and could induce the secretion of cytokines that might help in modulating immune responses.