สถาบันวิจัยวิทยาศาสตร์สาธารณสุข

National Institute of Health of Thailand

Serological and virological features of dengue fever and dengue haemorrhagic fever in Thailand from 1999 to 2002

Authors : Surapee Anantapreecha*, Sumalee Chanama*, Atchareeya A-nuegoonpipat*, Sirirat Naemkhunthot*, Areerat Sa-ngasang*, Pathom Sawanpanyalert *, Ichiro Kurane**

 

Affiliation:         *National Institute of Health, Department of Medical Sciences
                         **Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan
 
Source:             Epidemiology and Infection 2005; 133: 503-507
 
Language:         English
 
Abstract:
 
Serological and virological features of dengue fever (DF) and dengue haemorrhagic fever (DHF) in Thailand were analysed in 2715 patients from 1999 to 2002. The illness was caused by DEN-1 in 45%, DEN-2 in 32%, DEN-3 in 18% and DEN-4 in 5% of patients. Almost all of the DHF cases caused by DEN-2 and DEN-4 were in secondary infection, while approximately 20% of the DHF cases caused by DEN-1 and DEN-3 were in primary infection. Male:female ratio and age distribution were not different among four serotypes in primary and secondary infections. These results indicate that DEN-1 and DEN-3 induce DHF in both primary and secondary infections, and suggest that DEN-2 and DEN-4 in Thailand are less likely to cause DHF in primary infections.