สถาบันวิจัยวิทยาศาสตร์สาธารณสุข

National Institute of Health of Thailand

Authors : Atchareeya A-nuegoonpipat*, Alain Berlioz-Arthaud**, Vincent Chow***,Tim Endy****, Kym Lowry*****,Le Quynh Mai******, Truong Uyen Ninh******, Alyssa Pyke*******, Mark Reid********, Jean- Marc Reynes*********, Se-Thoe Su Yun**********,Hlaing Myat Thu***********, Sook-San Wong************, Edward C. Holmes*************, John Aaskov*****

 

Affiliation:      *National Institute of Health, Department of Medical Sciences
                   **Institute Pasteur, Noumea, New Caledonia, Australia
                   ***Department of Microbiology, National University of Singapore, Singapore
****Walter Reed Army Institute of Research, Silver Spring, USA
*****School of Life Sciences, Queensland University of Technology, Brisbane, Australia
******National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
*******Public Health Virology, Queensland Health Scientific Services, Coopers Plains, Australia
********Australian Army Malaria Institute, Brisbane, Australia
*********Institut Pasteur du Cambodge, Phnom Penh, Cambodia
**********Department of Pathology, Singapore General Hospital, Singapore
***********Department of Medical Research, Yangon, Myanmar
************Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia
*************Department of Zoology, University of Oxford, Oxford, UK
 
Source:         Virology 2004; 329: 505-512
 
Language:     English
 
Abstract:
 
Outbreaks of dengue due to dengue virus type 1 (DENV-1) occurred almost simultaneously in 2001 in Myanmar and at multiple sites almost 10,000 km away in the Pacific. Phylogenetic analyses of the E protein genes of DENV-1 strains recovered from Asia and the Pacific revealed three major viral genotypes (I, II, and III) with distinct clades within each. The majority of strains from the Pacific and Myanmar, and a number of other Asian strains fell into genotype I. Genotype II comprised a smaller set of Asian and Pacific strains, while genotype III contained viruses from diverse geographical localities. These analyses suggested that the continuing outbreak of dengue in the Pacific has been due to multiple, direct, introductions of dengue viruses from a variety of locations in Asia followed by local transmission. There was no evidence that theintroduction of these viruses into the Pacific was associated with any adaptive changes in the E protein of the viruses.