สถาบันวิจัยวิทยาศาสตร์สาธารณสุข

National Institute of Health of Thailand

Serum Lipoprotein (a) Levels in Healthy Thais

Authors : Panisa Getgern *, Pranee Chantapet*, Pratana Satitvipawee **

Affiliations:        * National Institute of Health, Department of Medical Sciences

** Department of Biostatistics, Faculty of Public Health,
Mahidol University, Bangkok
                       
Source:            Bulletin of Department of Medical Services 2003; 28: 97-105
 
Language:        Thai with English abstract
 
Abstract :
 
Serum lipoprotein (a) [Lp(a)] levels were determined in healthy Thai individuals by an enzyme linked immunosorbent assay (ELISA) in order to establish reference range and its relation with other lipids. Four hundred seventeen subjects (91 men and 362 women, 15-74 years of age), whose total cholesterol and high density lipoprotein cholesterol ratio were less than 5.0, participated. The results illustrated that Lp(a) levels were highly skewed towards low levels, with median of 98.0 milligram/liter (mg/l). The 25th and 75th percentiles were 55.5 and 172.5 mg/l, respectively. The reference range was 12.0 to 524.0 mg/l. No differences of Lp(a) levels between gender and age were observed. Approximately 18.9 % of all participants had Lp(a) level over 340.0 mg/l (above 80th percentile). The Lp(a) concentration did not correlate significantly with both triglyceride and high density lipoprotein cholesterol. Nevertheless, the correlations of Lp(a) with total cholesterol and low density lipoprotein cholesterol were weakly significant (r = 0.259 and 0.216; p< 0.001 respectively. Although the determination of serum Lp(a) levels depends on the method used and the population studied, our Lp(a) reference range may be useful for assessing risk of coronary heart disease in Thais.