สถาบันวิจัยวิทยาศาสตร์สาธารณสุข

NATIONAL INSTITUTE OF HEALTH OF THAILAND

No Effect of Garlic Extract Supplement on Serum Lipid Levels in Hypercholesterolemic Subjects

Authors : Satitvipawee P*, Rawdaree P**,Indrabhakti S,* Ratanasuwan T,***, Panisa Getgern****,Viwatwongkasem C*

 

Affiliations:     *Department of Biostatistics, Faculty of Public Health, Mahidol University,
Bangkok , 10400
**Endocrinology Unit, Department of Medicine, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Bangkok, 10300
                        ***Department of Medicine, Lerdsin Hospital, Bangkok, 10500
****National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi ,11000. Thailand
 
Source:           Journal of the Medical Association of Thailand 2003; 86: 750-757
 
Language:         English with Thai abstract
 
Abstract :
 
Objective : The authors assessed the effects of an enteric-coated Thai garlic extract tablet standardized for allicin-releasing potential on serum lipid levels in hypercholesterolemic subjects.
 
Subjects and Method : The authors performed a randomized, double-blind, placebo-controlled trial in 136 hypercholesterolemic subjects (cholesterol concentrations ³ 5.2 mmol/L; mean age ± SD: 47.0 ± 6.6 yr). All subjects were given dietary advice to lower fat intake within 4 weeks and were advised to eat normally during the study period. The subjects were randomly assigned to receive an enteric-coated Thai garlic extract tablet once daily (standardized to 1.12% allicin or 5.6 mg/tablet), or placebo after the evening meal for 12 weeks. Seventy subjects (32.9% male; mean age ± SD and BMI of 47.0 ± 6.6 yr and 24.6 ± 3.3 kg/m2) received the garlic extract treatment while 66 subjects (37.9% male, mean age ± SD and BMI of 47.0 ± 6.0 yr and 24.3 ± 3.4 kg/m2) received placebo.
 
Results : There were no statistically significant changes in serum total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol after the 12-week treatment asanalyzed on repeated measures by analysis of variance. In addition, no changes in plasma glucose, liver and renal functions were found.
 
Conclusions : Treatment with an enteric garlic-coated Thai garlic extract and dietary advice did not produce any significant changes in lipid levels in subjects with hypercholesterolemia.