Affiliations: *Division of Clinical Pathology, National Institute of Health,
Department of Medical Sciences, Ministry of Public Health,
Tivanon Road, Nonthaburi 11000, Thailand
Source: Southeast Asian Journal of Tropical Medicine and Public Health
1996; 27(1): 111-118
With the purpose to elucidate the pathogenesis of disease due to Burkholderia pseudomallei some biological and biochemical properties of this spicies were studied in comparison with B. cepacia, since the difference in the level of virulence between the two species is remarkable despite of their toxonomic closeness. B pseudomallei was distinct from B. cepacia in the capability to grow under anaerobic conditions, with positive nitrate respiration, excretion of high-molecular polysaccharides into liquid culture, and cytotoxicity against cultured tissue cells. From these observations together with our previous finding that B. pseudomallei can grow and survive in an acidic environment, we suggest multifactorial mechanisms for the pathogenesis of melioidosis due to B. pseudomallei.