สถาบันวิจัยวิทยาศาสตร์สาธารณสุข

NATIONAL INSTITUTE OF HEALTH OF THAILAND

National Antimicrobial Resistance Surveillance, Thailand (NARST)

Authors : Pakdee Pothisiri*, Mayura Kusum*, Pathom Sawanpanyalert*, Surang dejsirilert* and the Working Group

 

Affiliations:        *Department of Medical Sciences, Ministry of Public Health, Nonthaburi,
Thailand
 
Source:             ISAAR 2001, 3rd International Symposium on Antimicrobial Agents and Resistance: 1-13
 
 
Language:         English
 
 
Abstract:
 
Objective The NARSThas been established since 1998 to follow resistance trends and use the result to update treatment guideline and lists of essential drug.
Method In 1998-1999, 22 hospitals participated and were expanded to 33 in the year 2000. Results of routine antimicrobial susceptibility test, according to the NCCLS standard, were recorded by using the WHONET software and submittee to the coordinating center for analysis. To obtain the reliable results, the laboratory quality system is applied. The quality assurance activities include organizing yearly training course, strengthening the internal quality control, and proficiency testing. The center also conducts as National Reference Laboratory on species identification and confirmation of unusual susceptibility result of isolates sent from the members.
Result In the year 1998, 1999 and 2000, a total of 89,425, 113,843 and 79,386 isolates were tested by all members. E. coli, P. aeruginosa, K. pneumoniae and Acinetobacter spp. were the 5 most common isolates accounted for 60% for all isolates. Resistance among P. aeruginosa and Acinetobacter were resistant to most agents even to the effective Imipenam with the nonsusceptibility at 13% and 19% respectively. During 1998-2000 penicillin resistant pneumococci, vancomycin resistant enterococci and MRSA were atthe rate of 47-48, 3-7 and 22-39%. The significance increase of resistance were noted in S. pneumoniae isolated from sterile site of children < 5 years old from 34% in 1998 to 59% in 1999. MRSA isolated from patients seen at OPD increased from 10% in 1998 to 34% in 2000.
Conclusion The data from NARST provides useful information on threatening the future crisis of antibiotic resistant which will promote the awareness and concern on rational use of antibiotic and containment of antimicrobial resistance in the country.