สถาบันวิจัยวิทยาศาสตร์สาธารณสุข

National Institute of Health of Thailand

Serum Lipoprotein (a) and Lipid Levels in Type 2 Diabetic Patients : Relationship to the Level of Glycaemic Control

Authors : Panitsa Getngern*, Prachakvich Lepnak*, Pranee Chantapet*

 

Affiliations:        National Institute of Health, Department of Medical Sciences,
Nonthaburi Province, Thailand
 
Source:            Bulletin of Department of Medical Services 2001; 26: 509-518
 
Language:         Thai with English abstract
 
Abstract :
 
Serum lipoprotein(a)[Lp(a)], lipid and fructosamine levels were
determined in 121 Type 2 diabetic patients (44 males and 77 females ; median age of 58 years) and 100 non-diabetic subjects (36 males and 64 females ; median age of 53 years) in order to evaluate the incidence of Lp(a) and lipid disorder in diabetes, and to examine the relationship between Lp(a) levels and glycaemic control. Patients with Type 2 diabetes demonstrated significantly higher levels of Lp(a) and triglyceride when compared with non-diabetic subjects (136 vs 103 mg/l and 170 vs 95 mg/l, respectively, p < 0.05). There were no significant differences of total cholesterol, high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) between the study groups. The distribution of Lp(a) levels was highly skewed towards the lower levels in both groups, being over 300 mg/l in 28% of diabetic patients and only 8% of non-diabetics. Lp(a) level was not correlated with lipid levels and fructosamine concentrations in the patient group. These results suggest that serum Lp(a) in Type 2 diabetes is an independently risk factor for atherosclerotic cardiovascular disease, and does not depend upon the degree of glycaemic contol. Serum Lp(a) is useful in identifying high risk individuals need to be treated. In addition, high serum Lp(a) patients must be extremely managed to detect coronary artery disease inadvance.